Atypical Presentation of Acquired Hypoganglionosis in a Patient Taking Clozapine. (24th June 2020)

• Record Type: Journal Article
• Authors: Gisi, Catherine; Munteanu, Anamaria; Ku, Lawrence; French, Samuel; Fleischman, Michael; Eysselein, Viktor
• Other Names: Kikuchi Shiro Academic Editor.
• Is Part Of: Case reports in gastrointestinal medicine. Volume 2020(2020)
• Publication Date: 2020-06-24
• Subjects: Gastroenterology -- Case studies -- Periodicals; Digestive organs -- Diseases -- Periodicals; Gastroenterology; Gastrointestinal Diseases; Digestive organs -- Diseases; Gastroenterology; Electronic journals; Periodicals; Case studies; Periodicals; 616.33
• DOI: 10.1155/2020/1272567
• Languages: English
• ISSNs: 2090-6528

Abstract

Abstract : Acquired hypoganglionosis (HG) is a rare enteric gastrointestinal neuromuscular disorder previously associated with chronic inflammation that can lead to constipation, ileus, and even death. There is little known about the pathophysiology of acquired hypoganglionosis, and it is unclear if medications are related to the development of the disease. Clozapine is an atypical antipsychotic used to treat refractory schizophrenia that is well known for its side effects including agranulocytosis and gastrointestinal dysmotility. This is an unusual case of acquired hypoganglionosis in a patient with anticholinergic toxicity on clozapine therapy.