Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis. (28th July 2020)

• Record Type: Journal Article
• Authors: Zhou, Jingbin; Zhao, Zhihong; He, Chen; Gao, Feng; Guo, Yu; Qu, Feng; Liu, Yujie
• Other Names: Teng Zenghui Guest Editor.
• Is Part Of: Journal of immunology research. Volume 2020(2020)
• Publication Date: 2020-07-28
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2020/8127281
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : Osteoarthritis (OA) has long been considered as a degenerative disease, but growing evidence suggests that inflammation plays a vital role in its pathogenesis. Unlike rheumatoid arthritis and other autoimmune diseases, inflammation in OA is chronic and, in relatively low grade, mainly mediated by the innate immune system, especially macrophages. However, due to its low abundance, there is a lack of systematic studies on macrophages in the OA condition. Here, we have used single-cell RNA sequencing analysis to gain insight into the heterogeneity and functional specialization of human knee macrophages. We also compared the gene expression profiles of macrophages in healthy people and OA patients and found the characteristic changes of special macrophages in the OA knee. We believe that this in-depth understanding of the basis of OA inflammation will bring hope for the development of new therapies.