Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors. (14th April 2020)

• Record Type: Journal Article
• Authors: Roy, Vincent; Magne, Brice; Vaillancourt-Audet, Maude; Blais, Mathieu; Chabaud, Stéphane; Grammond, Emil; Piquet, Léo; Fradette, Julie; Laverdière, Isabelle; Moulin, Véronique J.; Landreville, Solange; Germain, Lucie; Auger, François A.; Gros-Louis, François; Bolduc, Stéphane
• Other Names: Daamen Willeke F. Academic Editor.
• Is Part Of: BioMed research international. Volume 2020(2020)
• Publication Date: 2020-04-14
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2020/6051210
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Cancer research has considerably progressed with the improvement of in vitro study models, helping to understand the key role of the tumor microenvironment in cancer development and progression. Over the last few years, complex 3D human cell culture systems have gained much popularity over in vivo models, as they accurately mimic the tumor microenvironment and allow high-throughput drug screening. Of particular interest, in vitro human 3D tissue constructs, produced by the self-assembly method of tissue engineering, have been successfully used to model the tumor microenvironment and now represent a very promising approach to further develop diverse cancer models. In this review, we describe the importance of the tumor microenvironment and present the existing in vitro cancer models generated through the self-assembly method of tissue engineering. Lastly, we highlight the relevance of this approach to mimic various and complex tumors, including basal cell carcinoma, cutaneous neurofibroma, skin melanoma, bladder cancer, and uveal melanoma.