Morphine Use in Renal Failure: A Case Report of Single-Dose Morphine Toxicity in a Patient Requiring Peritoneal Dialysis. (December 2020)

• Record Type: Journal Article
• Authors: Slater, Nicole A.; Todd, Anthony M.; Trimmier, Marirose C.; Campbell, Kristina C.
• Is Part Of: Journal of pharmacy practice. Volume 33:Number 6(2020:Dec.)
• Page Start: 903
• Page End: 906
• Publication Date: 2020-12
• Subjects: peritoneal dialysis -- M6G -- morphine toxicity -- morphine -- renal clearance -- hospice; Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1177/0897190019853992
• Languages: English
• ISSNs: 0897-1900

Abstract

Objective: We describe a case of morphine toxicity presumably caused by accumulation of its active metabolite morphine-6-glucuronide (M6G) secondary to reduced clearance by peritoneal dialysis. Methods: We present the relevant history and laboratory data and review pertinent literature regarding the use of opioids in renal failure. Results: A 76-year-old African-American female received one dose of morphine sulfate and developed signs and symptoms of morphine toxicity for 2 days, even after multiple peritoneal dialysis sessions. Conclusion: Because of reduced renal clearance of morphine and its metabolites in patients requiring peritoneal dialysis, morphine should be avoided as an analgesic option in this population due to increased risk of morphine toxicity.