When CKD-MBD is not just CKD-MBD, a case of humoral hypercalcemia of malignancy in a dialysis patient. Issue 3 (October 2020)

• Record Type: Journal Article
• Authors: Gandhi, Pulkit; Gandhi, Roopali Goyal; Shah, Ankur D
• Is Part Of: Journal of onco-nephrology. Volume 4:Issue 3(2020)
• Page Start: 128
• Page End: 131
• Publication Date: 2020-10
• Subjects: Hypercalcemia -- humoral hypercalcemia -- ESRD -- malignancy -- oral squamous cell cancer -- PTHrp; Nephrology -- Periodicals; Kidneys -- Cancer -- Periodicals; Kidneys -- Tumors -- Periodicals; 616.61
• DOI: 10.1177/2399369320951579
• Languages: English
• ISSNs: 2399-3693

Abstract

Patients on maintenance hemodialysis have dysregulations of calcium and phosphorus homeostasis which results in a plethora of mineral and bone pathologies. Management is typically focused on maintenance eucalcemia and limiting hyperphosphatemia while avoiding extremes of intact parathyroid hormone. Hypercalcemia in this setting is often iatrogenic. We present a case of humoral hypercalcemia of malignancy initially thought to be iatrogenic due to mineral bone management and discuss the overlap of management of hypercalcemia and management of mineral bone disease in end stage kidney disease. We highlight the relationship between malignancy and end stage kidney disease and the increased risk of hypercalcemia associated with malignancy.