A case of relapsing immunoglobulin A nephropathy secondary to immunotherapy. Issue 3 (October 2020)

• Record Type: Journal Article
• Authors: Mamlouk, Omar; Workeneh, Biruh
• Is Part Of: Journal of onco-nephrology. Volume 4:Issue 3(2020)
• Page Start: 87
• Page End: 91
• Publication Date: 2020-10
• Subjects: Immune checkpoint inhibitor -- immunoglobulin A nephropathy -- nephrotic syndrome -- repository corticotrophin therapy; Nephrology -- Periodicals; Kidneys -- Cancer -- Periodicals; Kidneys -- Tumors -- Periodicals; 616.61
• DOI: 10.1177/2399369320929347
• Languages: English
• ISSNs: 2399-3693

Abstract

An estimated 3% of patients treated with immune checkpoint inhibitors develop acute kidney injury during the treatment course. The majority of biopsy-proven checkpoint inhibitor–associated nephropathy is related to acute interstitial nephritis, but various glomerulonephritides have been reported, including immunoglobulin A nephropathy and minimal change disease. Secondary immunoglobulin A nephropathy can be associated with autoimmune and infectious disease, but, unlike minimal change disease, rarely as a result of medications. To date, there are no clear evidences that treating secondary immunoglobulin A nephropathy or minimal change disease with immunosuppression therapy provides resolution for glomerulonephritis. We report the first case of remission of checkpoint inhibitor–induced overlap immunoglobulin A/minimal change disease nephropathy treated with repository corticotrophin therapy.