Respiratory Rates Derived From Arterial Blood Pressure Waveforms in Telemetered Dogs. (November 2020)

• Record Type: Journal Article
• Authors: Tang, Hai-Ming; Laduke, Carrie; Reynolds, Dave; Carey, Cynthia; Hahn, Suzette; Friedrichs, Gregory S.
• Is Part Of: International journal of toxicology. Volume 39:Number 6(2020)
• Page Start: 542
• Page End: 546
• Publication Date: 2020-11
• Subjects: respiratory end points -- telemetered dog -- arterial blood pressure -- breathing rates -- methods; Toxicology -- Periodicals; 615.9005
• DOI: 10.1177/1091581820946703
• Languages: English
• ISSNs: 1091-5818

Abstract

The objective of this study was to extract low frequency respiratory "artifacts" from a standard arterial blood pressure (ABP) waveform to simultaneously derive reliable breathing rates (BR). Arterial blood pressure derived BR values were characterized against respiratory rates simultaneously obtained from the Respiratory Inductive Plethysmography (RIP) system (EMKA). Reference compounds were introduced to evaluate responsiveness of the derived measures to respiratory depressants and stimulants. Male beagle dogs (n = 3) were instrumented with minimally invasive telemetry devices for measurements of ABP and heart rate. The RIP system was utilized simultaneously to collect respiratory rate, tidal volume, and minute volume of each animal following pharmacological challenges. Early results revealed the derived BR's from ABP waveforms did not correlate well with those measured from the RIP system. Post study X-ray visualization revealed suboptimal catheter positioning, causing poor concordance of BR tallied from the ABP waveforms. Follow-up evaluations were conducted using additional animals instrumented with the ABP catheter tip placement advanced proximal to the thoracic diaphragm. Preliminary data from this subset of animals significantly improved the correlation of BR derived from ABP and respiratory rates recorded by the RIP. This proof of concept investigation was intended to evaluate an algorithm designed to extract additional data from routine cardiac waveforms. We clearly demonstrated that with optimal blood pressure catheter placement and acquisition algorithm, a reliable breathing rate can also be extracted from safety studies without the need for additional studies/animals to capture those respiratory end points.