Gastric cancer prevention strategies: A global perspective. Issue 9 (26th March 2020)

• Record Type: Journal Article
• Authors: Eusebi, Leonardo Henry; Telese, Andrea; Marasco, Giovanni; Bazzoli, Franco; Zagari, Rocco Maurizio
• Is Part Of: Journal of gastroenterology and hepatology. Volume 35:Issue 9(2020)
• Page Start: 1495
• Page End: 1502
• Publication Date: 2020-03-26
• Subjects: Chemoprevention -- Diagnosis -- Epidemiology -- Gastric cancer -- Prevention -- Screening -- Surveillance; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.15037
• Languages: English
• ISSNs: 0815-9319

Abstract

Abstract: Gastric cancer (GC) is the fifth most common cancer worldwide, and mortality rates are still high. Primary preventive strategies, aimed to reduce risk factors and promote protective ones, will lead to a decrease in GC incidence. Helicobacter pylori infection is a well‐established carcinogen for GC, and its eradication is recommended as the best strategy for the primary prevention. However, the role of other factors such as lifestyle, diet, and drug use is still under debate in GC carcinogenesis. Unfortunately, most patients with GC are diagnosed at late stages when treatment is often ineffective. Neoplastic transformation of the gastric mucosa is a multistep process, and appropriate diagnosis and management of preneoplastic conditions can reduce GC‐related mortality. Several screening strategies in relation to GC incidence have been proposed in order to detect neoplastic lesions at early stages. The efficacy of screening strategies in reducing GC mortality needs to be confirmed. This review provides an overview of current international guidelines and recent literature on primary and secondary prevention strategies for GC.