Mimicking SIV chimpanzee viral evolution toward HIV‐1 during cross‐species transmission. Issue 5 (17th August 2020)

• Record Type: Journal Article
• Authors: Schmitt, Kimberly; Curlin, James; Remling‐Mulder, Leila; Moriarty, Ryan; Goff, Kelly; O'Connor, Shelby; Stenglein, Mark; Marx, Preston; Akkina, Ramesh
• Is Part Of: Journal of medical primatology. Volume 49:Issue 5(2020)
• Page Start: 284
• Page End: 287
• Publication Date: 2020-08-17
• Subjects: Cross‐species SIV transmission -- HIV‐1 viral evolution from SIV -- hu‐HSC mice for cross‐species viral transmission -- SIV chimpanzee evolution toward HIV‐1 -- SIVcpz infection in humanized mice; Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12485
• Languages: English
• ISSNs: 0047-2565

Abstract

Abstract: HIV‐1 evolved from SIV during cross‐species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV‐1 Group M using humanized mice. High viral loads, rapid CD4 + T‐cell decline, and non‐synonymous substitutions were identified throughout the viral genome suggesting viral adaptation.