Evolution of SIVsm in humanized mice towards HIV‐2. Issue 5 (10th August 2020)

• Record Type: Journal Article
• Authors: Curlin, James; Schmitt, Kimberly; Remling‐Mulder, Leila; Moriarty, Ryan; Goff, Kelly; O'Connor, Shelby; Stenglein, Mark; Marx, Preston; Akkina, Ramesh
• Is Part Of: Journal of medical primatology. Volume 49:Issue 5(2020)
• Page Start: 280
• Page End: 283
• Publication Date: 2020-08-10
• Subjects: cross‐species SIV transmission -- HIV‐2 viral evolution -- hu‐HSC mice for viral cross‐species jump -- SIVsm evolution towards HIV‐2 -- SIVsm infection in humanized mice -- Sooty Mangabeys; Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12486
• Languages: English
• ISSNs: 0047-2565

Abstract

Abstract: Through the accumulation of adaptive mutations, HIV‐2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross‐species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4 + T‐cell decline as the virus was passaged in humanized mice.