Prognostic significance of smoking and alcohol history in young age oral cavity cancer. (4th June 2020)

• Record Type: Journal Article
• Authors: Lee, Sung Uk; Moon, Sung Ho; Choi, Sung Weon; Cho, Kwan Ho; Park, Joo Yong; Jung, Yuh‐Seok; Ryu, Junsun; Ryu, Chang Hwan; Yun, Tak; Kim, Tae Hyun; Youn, Sang Hee; Oh, Eun Sang
• Is Part Of: Oral diseases. Volume 26:Number 7(2020)
• Page Start: 1440
• Page End: 1448
• Publication Date: 2020-06-04
• Subjects: age groups -- alcohol drinking -- mouth neoplasm -- smoking -- survival; Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.13432
• Languages: English
• ISSNs: 1354-523X

Abstract

Abstract: Objective: To assess prognostic factors of patients with operable oral cavity squamous cell carcinoma (OSCC), focusing on the associations with smoking/alcohol exposure and age. Materials and Methods: A total of 247 patients with OSCC who received curative surgery ± adjuvant radiotherapy were analyzed. The patient subgroups were divided according to pretreatment smoking/alcohol exposure. Individuals aged 45 years or less were classified as younger patients. Results: The median follow‐up was 52.2 months. The 5‐year locoregional progression‐free survival (LRFFS), distant metastasis‐free survival (DMFS), overall survival (OS), and cancer‐specific survival (CSS) rates were 85.2%, 88.3%, 78.1%, and 83.5%, respectively. An advanced stage, differentiation, and lympho‐vascular space invasion were significantly associated with lower OS and CSS. In a subgroup analysis of younger patients ( n = 49), more smoking/alcohol exposure was significantly associated with better OS (hazard ratio [HR]: 0.21, 95% confidence interval [CI]: 0.05–0.95, p = .043). With increasing age, the HR for smoking/alcohol exposure with respect to OS increased up to 11.59 (95% CI: 1.49–89.84, p = .019) in older patients. Conclusion: Younger OSCC patients with non‐ or less smoking/alcohol exposure showed unfavorable outcomes. The prognostic significance of pretreatment smoking/alcohol exposure changed from favorable to detrimental with increasing age in operable OSCC.