Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases. (2nd July 2020)

• Record Type: Journal Article
• Authors: Wiggins, Claire J.; Chon, Susan Y.
• Other Names: Cuevas Covarrubias Sergio A. Academic Editor.
• Is Part Of: Case reports in dermatological medicine. Volume 2020(2020)
• Publication Date: 2020-07-02
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5005
• DOI: 10.1155/2020/8842242
• Languages: English
• ISSNs: 2090-6463

Abstract

Abstract : As aberrant Notch signaling has been linked to cancerous growth, Notch inhibitors represent a novel category of targeted oncological therapy. Notch pathways in tumor cells may contribute to proliferation or limit apoptosis and differentiation. Healthy skin differentiation and homeostasis are reliant on normal Notch expression, and disruption of this signaling has been implicated in dermatological conditions such as hidradenitis suppurativa, psoriasis, atopic dermatitis, and lichen planus. Here, we describe two cases of patients with cutaneous side effects from Notch inhibitor treatment for adenoid cyst carcinoma (ACC) and review the role of Notch signaling in skin disease. By illuminating connections between medication side effects and disease pathogenesis, our goal is to increase awareness of the cutaneous side effects of Notch inhibitor treatment.