Association of C1q/TNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease. (5th August 2020)

• Record Type: Journal Article
• Authors: Li, Zexuan; Du, Yunhui; Jia, Lixin; Fan, Jingyao; Guo, Ruifeng; Ma, Xinliang; Wang, Xiao; Nie, Shaoping; Wei, Yongxiang
• Other Names: Giovarelli Mirella Academic Editor.
• Is Part Of: Mediators of inflammation. Volume 2020(2020)
• Publication Date: 2020-08-05
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/2020/7281391
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : Background . Obstructive sleep apnea (OSA) is closely related to the incidence and progression of coronary artery disease (CAD), and the mechanisms linking OSA and CAD are multifactorial. C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that protects the heart against ischemic injury and ameliorates cardiac remodeling. We aimed to ascertain the clinical relevance of CTRP9 with OSA prevalence in patients with CAD. Methods . From August 2016 to March 2019, consecutive eligible patients with CAD (n = 154 ; angina pectoris, n = 88 ; acute myocardial infarction [AMI], n = 66 ) underwent cardiorespiratory polygraphy. OSA was defined as an apnea-hypopnea index (AHI) ≥15 events·h −1 . Plasma CTRP9 concentrations were measured by ELISA method. Results . Moderate/severe OSA was present in 89 patients (57.8%). CTRP9 levels were significantly decreased in the moderate/severe OSA group than in the no/mild OSA group (4.7 [4.1-5.2] ng/mL vs. 4.9 [4.4-6.0] ng/mL, P = 0.003 ). The difference between groups was only observed in patients with AMI (3.0 [2.3-4.9] vs. 4.5 [3.2-7.9], P = 0.009 ). Correlation analysis showed that CTRP9 levels were negatively correlated with AHI (r = − 0.238, P = 0.003 ) and oxygen desaturation index (r = − 0.234, P = 0.004 ) and positively correlated with left ventricular ejection fraction (r = 0.251, P = 0.004 ) in all subjects. Multivariate analysis showed that male gender (OR 3.099, 95% CI 1.029-9.330, P = 0.044 ), BMI (OR 1.148, 95% CI 1.040-1.268, P = 0.006 ), and CTRP9 levels (OR 0.726, 95% CI 0.592-0.890, P = 0.002 ) were independently associated with the prevalence of moderate/severe OSA. Conclusions . Plasma CTRP9 levels were independently related to the prevalence of moderate/severe OSA in patients with CAD, suggesting that CTRP9 might play a role in the pathogenesis of CAD exacerbated by OSA.