Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels. (24th March 2020)

• Record Type: Journal Article
• Authors: Yu, Lianlong; Yan, Jingyi; Zhang, Qian; Lin, Hong; Zhu, Lichao; Liu, Qiangqiang; Zhao, Changsheng
• Other Names: Iacobini Carla Academic Editor.
• Is Part Of: Journal of diabetes research. Volume 2020(2020)
• Publication Date: 2020-03-24
• Subjects: Diabetes -- Periodicals; Diabetes -- Pathophysiology -- Periodicals; Diabetes -- Prevention -- Periodicals; Diabetes -- Etiology -- Periodicals; Diabetes -- Epidemiology -- Periodicals; Diabetes -- Pathogenesis -- Periodicals; 616.462005
• DOI: 10.1155/2020/4138696
• Languages: English
• ISSNs: 2314-6745

Abstract

Abstract : This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were determined using standardized methods and conditions. Except for HDL-C, there was a significant increase in blood lipids in the progressive ferritin group with normal hs-CRP levels (P < 0.05 ). But HDL-C was just the opposite (P < 0.0001 ). In nondiabetic patients, TG, TC, and LDL-C were significantly elevated in the progressive ferritin group (P < 0.05 ). And, HDL-C was just the opposite (P < 0.05 ). The generalized linear model and the parsimonious model showed that serum TG was positively correlated with ferritin, and LDL-C was negatively correlated with ferritin (P < 0.05 ). But the correlation between LDL-C and ferritin was broken (P > 0.05 ). After a sufficient adjustment, there was a positive correlation between serum TG and ferritin and a negative correlation between LDL-C and ferritin. Nonetheless, a negative correlation between LDL-C and ferritin is influenced by diabetes frailly. And, there was no change of relationship between lipids and ferritin in different hs-CRP levels. We found a real relationship between ferritin and lipids after sufficient adjustment for confounders.