Metacognition in individuals recovered from anorexia nervosa: a voxel-based morphometry study. (30th October 2020)

• Record Type: Journal Article
• Authors: Oliva, Rossella; Baiano, Monica; Salvo, Pierandrea; Cereser, Lucia; Castiello, Umberto; Begliomini, Chiara
• Is Part Of: Psychiatry research. Volume 304(2020)
• Publication Date: 2020-10-30
• Subjects: Anorexia nervosa -- Recovery -- Voxel-based morphometry -- Metacognition -- Inferior frontal gyrus; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2020.111138
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: Recent evidence shows that individuals with Anorexia Nervosa (AN) can be characterized by dysfunctional metacognition as well as reductions of gray matter volumes (GMV) in prefrontal brain regions involved in cognitive processes. However, whether these differences are reversible or stable markers has yet to be understood. Thus, we aimed at characterizing metacognition and brain morphometry in individuals recovered from AN (rec-AN). A combined psychometric-brain morphometry investigation on metacognitive functioning in rec-AN individuals was conducted. Fifteen healthy controls (HC) and fifteen rec-AN women underwent a psychometric assessment for metacognitive functioning and a high-resolution T1-weighted Magnetic Resonance Imaging measurement to assess global and regional brain volumes, using Voxel-Based Morphometry. The two groups did not differ for metacognitive functioning and GMV, while regional GMV reductions were observed in rec-AN compared to HC in the left Inferior Frontal Gyrus (IFG). While changes in metacognitive abilities may not represent a stable trait of AN, regional GMV reductions in brain regions devoted to specific cognitive functions, such as inhibitory/top-down control processes, can act as a neurobiological fingerprint for such condition. These findings can represent a promising hint for future investigations on the maintaining factors of AN. Highlights: Rec-AN did not differ in their metacognitive profiles compared to HC. Between-group differences were found in the GMV of the left IFG. GMV of the IFG negatively correlated with thought control questionnaire's scores.