Biomimetic Nanocomposites Cloaked with Bioorthogonally Labeled Glioblastoma Cell Membrane for Targeted Multimodal Imaging of Brain Tumors. (23rd July 2020)

• Record Type: Journal Article
• Authors: Duan, Yukun; Wu, Min; Hu, Dehong; Pan, Yutong; Hu, Fang; Liu, Xingang; Thakor, Nitish; Ng, Wai Hoe; Liu, Xin; Sheng, Zonghai; Zheng, Hairong; Liu, Bin
• Is Part Of: Advanced functional materials. Volume 30:Number 38(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-23
• Subjects: biomimetic nanomaterials -- brain tumor targeting -- fluorescence imaging -- magnetic resonance imaging -- photoacoustic imaging; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202004346
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Brain tumor targeted delivery of diagnostic contrast agents has been an elusive goal due to the presence of the blood brain barrier (BBB) and the complex brain tumor microenvironment. Herein, an ingenious design of nanoscale contrast agents coated by bioorthogonally labeled brain tumor cell membrane for targeted diagnosis of glioblastoma through multiple complementary imaging modalities is presented. Taking advantage of bioorthogonal click reactions, an endothelial integrin receptor‐targeting peptide cRGD is decorated onto the nanocomposite surface to act in synergy with brain tumor cell membrane to offer BBB‐penetrating and homotypic targeting effect in the brain tumor microenvironment. Cellular and animal experimental results validate the superior targeting outcomes achieved by cRGD‐labeled brain tumor cell membrane coating. This study offers an example of a surface modified cell membrane as a potential theranostic strategy to overcome the delivery barriers in brain tumors. Abstract : Nanoscale contrast agents for enhanced glioblastoma targeting is presented. Nanocomposites coated by bioorthogonally labeled brain tumor cell membrane are developed and demonstrated for multimodal imaging of glioblastomas. An endothelial integrin receptor‐targeting peptide cRGD is decorated onto nanocomposite surface to act in synergy with brain tumor cell membranes to offer a BBB‐penetrating and homotypic targeting effect in brain tumor microenvironment.