"Search less, verify more"—Reviewing salivary biomarkers in oral cancer detection. (5th March 2020)

• Record Type: Journal Article
• Authors: Adeoye, John; Brennan, Peter A.; Thomson, Peter
• Is Part Of: Journal of oral pathology & medicine. Volume 49:Number 8(2020)
• Page Start: 711
• Page End: 719
• Publication Date: 2020-03-05
• Subjects: biomarkers -- oral squamous cell carcinoma -- saliva; Dentistry -- Periodicals; Teeth -- Diseases -- Periodicals; 617
• DOI: 10.1111/jop.13003
• Languages: English
• ISSNs: 0904-2512

Abstract

Abstract: Oral squamous cell carcinoma is one of the commonest head and neck malignancies with approximately 350 000 cases reported annually and a mortality rate of 50% often attributed to late clinical presentation. Due to the close relationship between saliva bio‐fluid and tumour lesions, optimizing salivary biomarkers for disease detection and screening provides a major new research direction in diagnostic oral oncology. As inter‐tumour heterogeneity and intra‐tumour heterogeneity are common within oral cavity neoplasms, it is unlikely that a single diagnostic or "risk‐stratifying" saliva biomarker will suffice for universal translation to clinical practice. Therefore, this article highlights a number of promising saliva biomarker combinations for oral cavity cancer detection that require further research and validation to determine their true diagnostic potential.