Synthesis and characterization of PEGylated iron and graphene oxide magnetic composite for curcumin delivery. (23rd June 2020)

• Record Type: Journal Article
• Authors: Abbasi, Reza; Mostafavi Amjad, Jafar; Nosrati, Hamed; Mohammadkhani, Ramin; Danafar, Hosein
• Is Part Of: Applied organometallic chemistry. Volume 34:Number 10(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-06-23
• Subjects: composite -- curcumin -- graphene oxide -- magnetic nanoparticles; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.5825
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : Nowadays, nanostructures have been given significant attention in medical and biological fields. Among these nanostructures, graphene oxide (GO) has been widely used in drug delivery systems, because of its unique properties, and the ability to connect to other nanostructures such as magnetic nanoparticles (NPs) as well as polymers by its functional groups. In this research, first, GO was prepared by exfoliating graphite according to the modified Hummer's method, and then the Fe3 O4 NPs were synthesized by a simple co‐precipitation method on GO nanosheets. In the next step, with the help of the ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide/ N ‐hydroxysuccinimide coupling reagents, the polyethylene glycol (PEG) polymer was bonded to the GO‐Fe3 O4 nanocomposite. Finally, anti‐cancer drug, curcumin (Cur) was loaded onto the nanocomposite and the Cur loading ratio was measured at about 8%. The samples were evaluated using Fourier transform‐infrared, differential scanning calorimtery, vibrating‐sample magnetometry, atomic force microscopy and dynamic light scattering techniques. The results show that the prepared nanocomposite is an appropriate candidate for biomedical applications. Abstract : The graphene oxide synthesized by improved Hammer's chemical method, and iron oxide magnetic nanoparticles were synthesized by co‐precipitation method on graphene oxide nanosheets. In the next step, the polyethylene glycol polymer was bonded to the graphene oxide‐iron nanocomposite, then curcumin was loaded onto the nanocomposite. The samples were evaluated using FTIR, DSC, VSM, AFM and DLS techniques. The result shows that as synthesized nanocomposite is an appropriate drug carrier.