LRRK2 to the rescue of damaged endomembranes. (16th August 2020)

• Record Type: Journal Article
• Authors: Radulovic, Maja; Stenmark, Harald
• Is Part Of: EMBO journal. Volume 39:Number 18(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-16
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.2020106162
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : Mutations in several genes encoding for lysosomal proteins are involved in Parkinson's disease (PD). In this issue, Herbst et al (2020) show that PD‐related leucine‐rich repeat kinase 2 (LRRK2) is activated in response to pathogen or membranolytic drug‐induced damage of phagolysosomes and lysosomes in macrophages, and regulates endolysosomal homeostasis by controlling the balance between membrane repair and degradation. Abstract : A new study shows that LRRK2 regulates phagolysosome and lysosome homeostasis in macrophages by controlling the balance between membrane repair and degradation.