Bioimaging: Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study (Small 37/2020). Issue 37 (17th September 2020)

• Record Type: Journal Article
• Authors: Ding, Ling; Lyu, Zhenbin; Louis, Beatrice; Tintaru, Aura; Laurini, Erik; Marson, Domenico; Zhang, Mengjie; Shao, Wanxuan; Jiang, Yifan; Bouhlel, Ahlem; Balasse, Laure; Garrigue, Philippe; Mas, Eric; Giorgio, Suzanne; Iovanna, Juan; Huang, Yuanyu; Pricl, Sabrina; Guillet, Benjamin; Peng, Ling
• Is Part Of: Small. Volume 16:Issue 37(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-09-17
• Subjects: dendrimers -- metal chelators -- self‐assembly -- SPECT imaging -- supramolecular nanosystems -- surface charge; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202070203
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : In article number 2003290, Ling Peng and co‐workers report a self‐assembling supramolecular dendrimer probe for tumor imaging by single photon emission computed tomography (SPECT). Altering the radionuclide chelators on the dendrimer surface leads to a highly favorable biodistribution profile with a drastically reduced uptake in liver and a significantly improved tumor imaging contrast.