Meningitis and bacteremia by nonhemolytic Group B Streptococcus strain: A whole genome analysis. (21st July 2020)

• Record Type: Journal Article
• Authors: Shimizu, Akihiko; Tsukagoshi, Hiroyuki; Sekizuka, Tsuyoshi; Kuroda, Makoto; Koizumi, Aya; Fujita, Masahiro; Yamada, Yoshiyuki; Saruki, Nobuhiro
• Is Part Of: Microbiology and immunology. Volume 64:Number 9(2020)
• Page Start: 630
• Page End: 634
• Publication Date: 2020-07-21
• Subjects: cylA -- meningitis -- nonhemolytic strain -- Streptococcus agalactiae; Microbiology -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Microbiologie -- Périodiques; Immunologie -- Périodiques; 579
• DOI: 10.1111/1348-0421.12826
• Languages: English
• ISSNs: 0385-5600

Abstract

Abstract: Group B streptococcus (GBS) is a leading cause of neonatal infections. Most isolates are β‐hemolytic, and their activity is considered to be pivotal for GBS pathogenicity. We report a case of a neonate with meningitis caused by nonhemolytic GBS. The patient developed meningitis 3 days after birth. Genotyping was performed and the characteristics of the strain (GCMC97051) identified by whole genome sequence using next generation sequencing. GCMC97051 possesses genetic alterations such as disruption of cylA by IS 1381A insertion and a frameshift mutation in cylE, resulting in a lack of hemolysis. Thus, nonhemolytic GBS can retain the potential to cause invasive infections.