Electro-responsive hydrogel-based microfluidic actuator platform for photothermal therapy. Issue 18 (4th August 2020)

• Record Type: Journal Article
• Authors: Ha, Jang Ho; Shin, Ha Hee; Choi, Hyung Woo; Lim, Jae Hyun; Mo, Sung Joon; Ahrberg, Christian D.; Lee, Jong Min; Chung, Bong Geun
• Is Part Of: Lab on a chip. Volume 20:Issue 18(2020)
• Page Start: 3354
• Page End: 3364
• Publication Date: 2020-08-04
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/d0lc00458h
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : Electrical stimuli play an important role in regulating the delivery of plasmonic nanomaterials with cancer targeting peptides. Abstract : Electrical stimuli play an important role in regulating the delivery of plasmonic nanomaterials with cancer targeting peptides. Here, we developed an electro-responsive hydrogel-based microfluidic actuator platform for brain tumor targeting and photothermal therapy (PTT) applications. The electro-responsive hydrogels consisted of highly conductive silver nanowires (AgNWs) and biocompatible collagen I gels. We confirmed that an electrically conductive hydrogel could be used as an effective actuator by applying an electrical signal in the microfluidic platform. Furthermore, we successfully demonstrated PTT efficacy for brain tumor cells using targetable Arg-Gly-Asp (RGD) peptide-conjugated gold nanorods (GNRs). Therefore, our electro-responsive hydrogel-based microfluidic actuator platform could be useful for electro-responsive intelligent nanomaterial delivery and PTT applications.