Amplisins A–E, chromone methide polymers with hypoglycemic activity from a new fungicolous fungus Amplistroma fungicola. Issue 18 (1st September 2020)

• Record Type: Journal Article
• Authors: Chen, Baosong; Han, Junjie; Wang, Mengmeng; Dai, Huanqin; Zhang, Jinjin; Cai, Lei; Wei, Shenglong; Zhang, Xue; Liu, Hongwei
• Is Part Of: Organic chemistry frontiers. Volume 7:Issue 18(2020)
• Page Start: 2761
• Page End: 2769
• Publication Date: 2020-09-01
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo00851f
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Five new non-enzymatic 1, 4-Michael addition of chromone methide polymers, (±)-amplisins A–D (1–4 ) and amplisin E (5 ), with hypoglycemic and anti-inflammatory activities, were isolated from a new fungicolous fungus Amplistroma fungicola . Abstract : Five new chromone methide polymers, (±)-amplisins A–D (1–4 ) and amplisin E (5 ), were isolated from a new fungicolous fungus Amplistroma fungicola . Compounds 1–5 were determined to have unusual chemical skeletons with two or three chromone methide groups linked with different polyketides. A non-enzymatic 1, 4-Michael addition of chromone methide was verified in the biosynthesis of 1–5 . Compounds 1 and 2 showed inhibition of PTP1B and stimulation of glucose uptake in insulin-resistant HepG2 cells. Compounds 3–5 exhibited strong NO inhibition of LPS-activated macrophages.