High-throughput screening of bioactive compounds via new catalytic reaction in the pooled mixture. Issue 19 (1st October 2019)

• Record Type: Journal Article
• Authors: Satoh, Ayano; Nishina, Yuta
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 29:Issue 19(2019)
• Publication Date: 2019-10-01
• Subjects: Golgi -- Secretion -- Brefeldin A -- Bisindole -- High-throughput screening; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2019.06.061
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: To increase the chances of finding new candidate molecules with medicinal properties, while expending less resource and effort, the present study used pooled substrates as starting materials. A bisindole compound that showed inhibitory activity was then isolated from the mixture, and the activity was improved by optimizing the substituents on the indole skeleton.