Synthesis and antitumor activity of daunorubicin conjugates with of 3, 4-methylendioxybenzaldehyde. Issue 19 (1st October 2019)

• Record Type: Journal Article
• Authors: Moiseeva, Aleksandra A.; Artyushin, Oleg I.; Anikina, Lada V.; Brel, Valery K.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 29:Issue 19(2019)
• Publication Date: 2019-10-01
• Subjects: Anthracycline antibiotics -- Daunorubicin -- Anticancer activity -- Antitumor conjugates; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2019.08.021
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: The design of hybrid (chimeric) molecules containing two different pharmacophores connected via a spacer (linker) is a promising approach to the functionalization of natural compounds and potentially of drug molecules. These are important examples for the use of this approach with anthracycline antibiotics. The use of this methodology may help to eliminate some of the drawbacks of anthracycline drugs, e.g., high cardiotoxicity and MDR development.