Cervical human papillomavirus among women in Guangdong, China 2008‐2017: Implication for screening and vaccination. Issue 10 (3rd July 2019)

• Record Type: Journal Article
• Authors: Luo, Ganfeng; Sun, Xiaoli; Li, Meijuan; Liu, Tingyan; Hu, Guiying; He, Yu; Mao, Lingzhi; Yan, Lingmei; Xie, Longxu; Zou, Huachun; Luo, Xiping
• Is Part Of: Journal of medical virology. Volume 91:Issue 10(2019)
• Page Start: 1856
• Page End: 1865
• Publication Date: 2019-07-03
• Subjects: cervical cancer -- China -- Guangdong -- human papillomavirus -- prevalence; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.25520
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract: Our study aimed to analyze genotype‐specific, age‐specific prevalence, and year‐on‐year trend of cervical human papillomavirus (HPV) detection among women in Guangdong, China 2008 to 2017. A total of 199 963 women attending the gynecological department and 11 999 women attending the medical examination center at Guangdong Women and Children Hospital were included. Prevalent HPV detection significantly differed between these two groups of women (20.16% vs 17.25%; P < .001). HPV genotypes of these two populations have a large overlap, with HPV52, 16, 58, CP8304, and 53 being the dominant subtypes among gynecological outpatients and HPV52, CP8304, 58, 53, and 16 among women receiving physical examinations. The distribution of prevalent HPV detection showed a bimodal pattern across age groups among these two populations. However, prevalent HPV detection among these two populations exhibited different trends from 2008 to 2017. Our study demonstrated that prevalent HPV detection among women in Guangdong is associated with age and different from that among women from other regions of China. Our study may provide valuable data to inform cervical cancer screening and HPV vaccination programs for women in this province. Highlight: This study summarized distribution characteristics and temporal trends of cervical HPV from large samples among gynecological outpatients and women receiving physical examinations in Guangdong of China during 2008‐2017. Prevalent HPV detection significantly differed among these two populations, but the dominant HPV subtypes have a large overlap, which can exactly provide a reference for the vaccine. Different trend curves of any HPV detection were observed among these two populations during 2008‐2017, which should be further investigated with more data from other hospitals and deserved closer attentions by public health specialists. Prevalent HPV detection among gynecological outpatients in the 20‐24 and >54 years old group both showed an upward trend during 2008‐2017, which can provide objective evidence for the selection of the younger age group for vaccination and provided clinical guideline for perimenopausal women in cervical cancer screening.