Modified Profile of Matrix Metalloproteinase 2 and 9 Production by Human Fallopian Tube Epithelial Cells After Infection In Vitro With Neisseria gonorrhoeae. (8th December 2016)

• Record Type: Journal Article
• Authors: Rodas, Paula I.; Pérez, Doris; Jauffret, Claudia; González, Yaquelin; Carreño, Carolina; Tapia, Cecilia V.; Osorio, Eduardo; Velasquez, Luis A.; Christodoulides, Myron
• Is Part Of: Journal of infectious diseases. Volume 215:Number 3(2017:Feb. 01)
• Page Start: 452
• Page End: 455
• Publication Date: 2016-12-08
• Subjects: extracellular matrix -- human Fallopian tube epithelial cells -- matrix metalloproteinases -- Neisseria gonorrhoeae.; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiw568
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.