SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan. (12th August 2016)

• Record Type: Journal Article
• Authors: Roichman, Asael; Kanfi, Yariv; Glazz, Renana; Naiman, Shoshana; Amit, Uri; Landa, Natalie; Tinman, Simon; Stein, Ilan; Pikarsky, Eli; Leor, Jonathan; Cohen, Haim Y.
• Is Part Of: Journals of gerontology. Volume 72:Number 5(2017:May)
• Page Start: 603
• Page End: 615
• Publication Date: 2016-08-12
• Subjects: Sirtuins -- Adipose inflammation -- Voluntary activity -- AMPK; Geriatrics -- Periodicals; Gerontology -- Periodicals; 618.97
• DOI: 10.1093/gerona/glw152
• Languages: English
• ISSNs: 1079-5006

Abstract

Abstract: The extension in human lifespan in the last century results in a significant increase in incidence of age related diseases. It is therefore crucial to identify key factors that control elderly healthspan. Similar to dietary restriction, mice overexpressing the NAD + dependent protein deacylase SIRT6 (MOSES) live longer and have reduced IGF-1 levels. However, it is as yet unknown whether SIRT6 also affects various healthspan parameters. Here, a range of age related phenotypes was evaluated in MOSES mice. In comparison to their wild-type (WT) littermates, old MOSES mice showed amelioration of a variety of age-related disorders, including: improved glucose tolerance, younger hormonal profile, reduced age-related adipose inflammation and increased physical activity. The increased activity was accompanied with increased muscle AMP-activated protein kinase (AMPK) activity. Altogether, these results indicate that overexpression of SIRT6 in mice retards important aspects of the aging process and suggest SIRT6 to be a potential therapeutic target for the treatment of a set of age-related disorders.