Archaic Adaptive Introgression in TBX15/WARS2. (22nd December 2016)
- Record Type:
- Journal Article
- Title:
- Archaic Adaptive Introgression in TBX15/WARS2. (22nd December 2016)
- Main Title:
- Archaic Adaptive Introgression in TBX15/WARS2
- Authors:
- Racimo, Fernando
Gokhman, David
Fumagalli, Matteo
Ko, Amy
Hansen, Torben
Moltke, Ida
Albrechtsen, Anders
Carmel, Liran
Huerta-Sánchez, Emilia
Nielsen, Rasmus - Abstract:
- Abstract : A recent study conducted the first genome-wide scan for selection in Inuit from Greenland using single nucleotide polymorphism chip data. Here, we report that selection in the region with the second most extreme signal of positive selection in Greenlandic Inuit favored a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome, and was likely introgressed from an archaic population. The region contains two genes, WARS2 and TBX15, and has previously been associated with adipose tissue differentiation and body-fat distribution in humans. We show that the adaptively introgressed allele has been under selection in a much larger geographic region than just Greenland. Furthermore, it is associated with changes in expression of WARS2 and TBX15 in multiple tissues including the adrenal gland and subcutaneous adipose tissue, and with regional DNA methylation changes in TBX15 .
- Is Part Of:
- Molecular biology and evolution. Volume 34:Number 3(2017:Mar.)
- Journal:
- Molecular biology and evolution
- Issue:
- Volume 34:Number 3(2017:Mar.)
- Issue Display:
- Volume 34, Issue 3 (2017)
- Year:
- 2017
- Volume:
- 34
- Issue:
- 3
- Issue Sort Value:
- 2017-0034-0003-0000
- Page Start:
- 509
- Page End:
- 524
- Publication Date:
- 2016-12-22
- Subjects:
- adaptive introgression -- Denisova -- positive selection -- Native Americans -- methylation -- admixture.
Molecular biology -- Periodicals
Molecular evolution -- Periodicals
Evolution, Molecular -- Periodicals
Molecular Biology -- Periodicals
572.8 - Journal URLs:
- http://mbe.oxfordjournals.org/ ↗
http://www.molbiolevol.org/ ↗
http://ukcatalogue.oup.com/ ↗
http://firstsearch.oclc.org ↗
http://firstsearch.oclc.org/journal=0737-7038;screen=info;ECOIP ↗ - DOI:
- 10.1093/molbev/msw283 ↗
- Languages:
- English
- ISSNs:
- 0737-4038
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5900.782000
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