Elevated Pre–Antiretroviral Therapy CD39+CD8+ T Cell Frequency Is Associated With Early Mortality in Advanced Human Immunodeficiency Virus/Tuberculosis Co-infection. (16th February 2017)

• Record Type: Journal Article
• Authors: Ravimohan, Shruthi; Tamuhla, Neo; Nfanyana, Kebatshabile; Ni, Houping; Steenhoff, Andrew P.; Gross, Robert; Weissman, Drew; Bisson, Gregory P.
• Is Part Of: Clinical infectious diseases. Volume 64:Number 10(2017)
• Page Start: 1453
• Page End: 1456
• Publication Date: 2017-02-16
• Subjects: HIV -- tuberculosis -- early mortality -- CD39 -- CD8+ T cells.; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/cix155
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Correlates of death soon after antiretroviral therapy (ART) initiation remain unclear. We investigated the association between expression of CD39, a novel immune exhaustion marker, and early mortality in patients with human immunodeficiency virus/tuberculosis co-infection. Elevated pre-ART CD39 + CD8 + T cell frequency was independently associated with mortality within 6 months of ART initiation.