Near‐Infrared Activated Black Phosphorus as a Nontoxic Photo‐Oxidant for Alzheimer's Amyloid‑β Peptide. Issue 24 (8th May 2019)

• Record Type: Journal Article
• Authors: Li, Yang; Du, Zhi; Liu, Xinping; Ma, Mengmeng; Yu, Dongqin; Lu, Yao; Ren, Jinsong; Qu, Xiaogang
• Is Part Of: Small. Volume 15:Issue 24(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-05-08
• Subjects: Alzheimer's disease -- amyloid‐β -- black phosphorus -- nontoxic photo‐oxidants -- photo‐oxygenation -- singlet oxygen; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201901116
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: The inhibition of amyloid‐β (Aβ) aggregation by photo‐oxygenation has become an effective way of treating Alzheimer's disease (AD). New near‐infrared (NIR) activated treatment agents, which not only possess high photo‐oxygenation efficiency, but also show low biotoxicity, are urgently needed. Herein, for the first time, it is demonstrated that NIR activated black phosphorus (BP) could serve as an effective nontoxic photo‐oxidant for amyloid‑β peptide in vitro and in vivo. The nanoplatform BP@BTA (BTA: one of thioflavin‐T derivatives) possesses high affinity to the Aβ peptide due to specific amyloid selectivity of BTA. Importantly, under NIR light, BP@BTA can significantly generate a high quantum yield of singlet oxygen ( 1 O2 ) to oxygenate Aβ, thereby resulting in inhibiting the aggregation and attenuating Aβ‐induced cytotoxicity. In addition, BP could finally degrade into nontoxic phosphate, which guarantees the biosafety. Using transgenic Caenorhabditis elegans CL2006 as AD model, the results demonstrate that the 1 O2 ‐generation system could dramatically promote life‐span extension of CL2006 strain by decreasing the neurotoxicity of Aβ. Abstract : Photoexcited black phosphorus (BP) is used as a nontoxic photooxidant of amyloid‐β (Aβ) for Alzheimer's disease (AD) treatment. Under near‐infrared illumination, the BP‐based hybrid nanosheets generate singlet oxygen ( 1 O2 ), thereby inhibiting aggregation of Aβ by selectively oxidizing the β‐sheet aggregates. Moreover, the nanoplatform can attenuate Aβ‐triggered toxicity to prolong the life‐span of AD model Caenorhabditis elegans CL2006 strain.