Regional gastrointestinal contractility parameters using the wireless motility capsule: inter‐observer reproducibility and influence of age, gender and study country. Issue 3 (6th December 2017)

• Record Type: Journal Article
• Authors: Farmer, A. D.; Wegeberg, A.‐M. L.; Brock, B.; Hobson, A. R.; Mohammed, S. D.; Scott, S. M.; Bruckner‐Holt, C. E.; Semler, J. R.; Hasler, W. L.; Hellström, P. M.; Drewes, A. M.; Brock, C.
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 47:Issue 3(2018)
• Page Start: 391
• Page End: 400
• Publication Date: 2017-12-06
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.14438
• Languages: English
• ISSNs: 0269-2813

Abstract

Summary: Background: The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. Aims: To describe normative values for motility/contractility parameters across age, gender and testing centres. Methods: Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter‐observer agreement was independently assessed by 2 investigators. Results: Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40 years, range 18‐78). MotiliGI ‐ Gastric, small bowel and colonic maximal contraction amplitude correlated with age ( r = .24, P = .01; r = .22, P = .02; and r = .2, P = .04 respectively). Small bowel motility index was higher in females than males (150.4 ± 12 vs 122 ± 7.6, P = .04). Inter‐observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer ‐ Gastric, small bowel and colonic loge motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r >.35, P < .0003) but not with transit times. Conclusions: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders.