Clinical and Ultrasonographic Evaluation of Infantile Periocular Hemangioma Treated With Oral Propranolol. Issue 5 (September 2019)

• Record Type: Journal Article
• Authors: Jamshidian-Tehrani, Mansooreh; Nabavi, Amin; Taghavi, Mostafa; Sharif-Kashani, Shervin; Kasaee, Abolfazl; Sadeghi-Tari, Ali; Mirhosseini, Mohammad; Nowroozzadeh, M. Hossein
• Is Part Of: Ophthalmic plastic and reconstructive surgery. Volume 35:Issue 5(2019)
• Publication Date: 2019-09
• Subjects: Eye -- Surgery -- Periodicals; Ophthalmic plastic surgery -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Ophthalmologic Surgical Procedures -- Periodicals; Ophthalmology -- Periodicals; Surgery -- Periodicals; 617.70592
• DOI: 10.1097/IOP.0000000000001336
• Languages: English
• ISSNs: 0740-9303

Abstract

Abstract : Purpose: To evaluate the clinical and ultrasonographic response of periocular infantile capillary hemangioma during treatment with oral propranolol. Methods: Patients with infantile periocular hemangioma and visual or cosmetic concerns were enrolled in this prospective interventional case series. Propranolol was given at a dose of 2 mg/kg per day for at least 6 months. Evaluation of treatment response was performed at month 3 (time point 1) and month 6 (time point 2). Gray scale ultrasonography and color Doppler imaging were performed at baseline and month 3. Results: Thirty-one patients with mean age of 4.1 ± 2.3 months were eligible for analysis. Complete or near complete clinical resolution was observed in 4 patients (12.9%) at time point 1 and 21 patients (67.7%) at time point 2. Longitudinal diameter, transverse diameter, thickness, arterial peak systolic velocity, and end diastolic velocity reduced significantly from baseline to 3-month follow up. Complete clinical response at time point 2 was significantly higher in patients with peak systolic velocity reduction >50% from baseline to month 3 than patients with peak systolic velocity reduction of 10% to 50% and <10%. Conclusions: Propranolol is safe and effective for infantile periocular hemangioma. Ultrasonography and color Doppler imaging are useful modalities to monitor and predict the treatment response. Abstract : This prospective interventional case-series evaluated the effect of systemic propranolol (2 mg/kg) on 31 patients with infantile periocular hemangioma and found near-complete clinical resolution in 67.7%, which was confirmed with gray-scale ultrasonography and Color-Doppler imaging.