Development of an inhibitor in a child with severe hemophilia B: treatment with immunosuppression and an extended desensitization protocol. Issue 6 (September 2019)

• Record Type: Journal Article
• Authors: Roberts, Jonathan C.; Jesudas, Rohith; Tarantino, Michael D.
• Is Part Of: Blood coagulation and fibrinolysis. Volume 30:Issue 6(2019)
• Publication Date: 2019-09
• Subjects: desensitization -- hemophilia B -- immune tolerance induction -- inhibitor; Blood -- Coagulation -- Periodicals; Fibrinolysis -- Periodicals; Hemostasis -- Periodicals; Thrombosis -- Periodicals; Blood Coagulation -- Periodicals; Fibrinolysis -- Periodicals; Hemostasis -- Periodicals; Thrombosis -- Periodicals; 612.115
• DOI: 10.1097/MBC.0000000000000829
• Languages: English
• ISSNs: 0957-5235

Abstract

Abstract : N/A: Development of neutralizing alloantibodies in hemophilia B is a less common, but clinically challenging phenomenon. Novel therapeutics for hemophilia B have recently been developed and reports of clinical experience with these agents outside of clinical trials are needed. We report development of an inhibitor in a child with severe hemophilia B, and subsequent immune tolerance induction using an extended desensitization protocol with the addition of immunosuppression. This case highlights successful management of a rare complication in a rare bleeding disorder and the need for additional investigation into this infrequent and clinically challenging occurrence.