Anomalous origins of the coronary arteries: current knowledge and future perspectives. (September 2019)

• Record Type: Journal Article
• Authors: Mazine, Amine; Fernandes, Ian M.; Haller, Christoph; Hickey, Edward J.
• Is Part Of: Current opinion in cardiology. Volume 34:Number 5(2019:Sep.)
• Publication Date: 2019-09
• Subjects: anomalous aortic origin of a coronary artery -- anomalous left coronary artery arising from the pulmonary artery -- congenital coronary anomalies -- embryology -- sudden cardiac death; Cardiology -- Periodicals; Cardiology -- Periodicals; Heart Diseases -- Periodicals; Cardiology; Periodicals; 616.12
• DOI: 10.1097/HCO.0000000000000663
• Languages: English
• ISSNs: 0268-4705

Abstract

Abstract : Purpose of review: The purpose of this review is to survey the contemporary literature surrounding congenital anomalies of origin of the coronary arteries and to identify remaining gaps in knowledge. Recent findings: In recent years, lineage tracing analyses and mechanistic studies in model organisms have enhanced our understanding of the normal embryologic development of the coronary arteries, and how disruption of this intricate process can lead to congenital coronary anomalies. The true incidence of these anomalies remains unknown. Although a majority of cases are believed to be clinically silent, clinical presentation varies widely, from asymptomatic to sudden cardiac death. Cardiac computed tomography angiography and/or magnetic resonance angiography are the mainstay diagnostic modalities. Management of anomalous coronary arteries depends on the morphology and clinical presentation. Surgery is the gold-standard treatment for anomalous left coronary artery arising from the pulmonary artery and anomalous aortic origin of a coronary artery with intramural or interarterial course. Summary: Several large multicenter initiatives are currently underway and should help address some of the numerous knowledge gaps surrounding the evaluation and management of anomalous coronary arteries.