Efficacy of 177Lu Peptide Receptor Radionuclide Therapy for the Treatment of Neuroendocrine Tumors: A Meta-analysis. (September 2019)

• Record Type: Journal Article
• Authors: Saravana-Bawan, Bianka; Bajwa, Amandeep; Paterson, John; McEwan, Alexander J. B.; McMullen, Todd P. W.
• Is Part Of: Clinical nuclear medicine. Volume 44:Number 9(2019)
• Publication Date: 2019-09
• Subjects: lutetium -- NET -- neuroendocrine tumor -- PRRT; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002646
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Objective: The purpose of this study was to assess the efficacy of 177 Lu-labeled peptide receptor radionuclide therapy (PRRT) induction treatments for patients with unresectable metastatic neuroendocrine tumors. Methods: MEDLINE, EMBASE, and Ovid were systematically searched with keywords "lutetium, " "Lu-177, " "PRRT, " "neuroendocrine, " and "prognosis." Studies evaluating treatment with 177 Lu-labeled PRRT were assessed for disease response and/or disease control rate by Response Evaluation Criteria in Solid Tumors (RECIST) 1.0 or 1.1, modified RECIST, Southwest Oncology Group (SWOG), or modified SWOG criteria. Pooled proportions of disease response and control rates were calculated for both fixed- and random-effects models. Results: Eighteen studies with 1920 patients were included (11 with 1268 patients using RECIST and 6 with 804 patients using SWOG). By RECIST criteria, the pooled disease response rate by random-effects model was 29.1% (95% confidence interval [CI], 20.2%–38.9%), and disease control rate was 74.1% (95% CI, 67.8%–80.0%). By SWOG criteria, the pooled disease response rate by random-effects model was 30.6% (95% CI, 20.7%–41.5%), and disease control rate was 81.1% (95% CI, 76.4%–85.4%). Conclusions: Induction therapy, typically 4 treatments, with 177 Lu PRRT is an effective method of treating unresectable metastatic neuroendocrine tumors with significant disease response and control rates.