Comparison of Mohs Surgery and Surgical Excision in the Treatment of Localized Sebaceous Carcinoma. Issue 9 (September 2019)

• Record Type: Journal Article
• Authors: Su, Chang; Nguyen, Kevin A.; Bai, Harrison X.; Christensen, Sean R.; Cao, Ya; Tao, Yongguang; Karakousis, Giorgos; Zhang, Paul J.; Zhang, Guiying; Xiao, Rong
• Is Part Of: Dermatologic surgery. Volume 45:Issue 9(2019)
• Publication Date: 2019-09
• Subjects: Skin -- Surgery -- Periodicals; Skin -- Diseases -- Surgery -- Periodicals; 617.477
• DOI: 10.1097/DSS.0000000000001780
• Languages: English
• ISSNs: 1076-0512

Abstract

Abstract : BACKGROUND: It remains controversial if Mohs surgery is superior to surgical excision in treating localized sebaceous carcinoma. OBJECTIVE: To compare Mohs surgery and surgical excision for treating patients with localized sebaceous carcinoma. MATERIALS AND METHODS: The US National Cancer Database was used to identify patients with histologically confirmed Stage 0 to 2 sebaceous carcinoma from 2004 to 2014. Clinicopathologic and socioeconomic factors were compared between treatment groups using the chi-square test. Overall survival (OS) was evaluated by log-rank test, multivariable Cox proportional hazard regression, and propensity score–matched analysis. Relative survival analyses compared with age- and sex-matched US population were performed. RESULTS: Of 1, 265 patients, 234 received Mohs surgery and 1, 031 received surgical excision. Mohs surgery had a higher rate of negative margin ( p = .004). On multivariate Cox regression analysis, Mohs surgery was associated with longer OS than surgical excision (HR: 0.703, 95% CI: 0.496–0.995, p = .047). The survival benefit of Mohs surgery persisted on relative survival analysis and propensity score–matched analysis ( p = .0385), after matching the 2 groups on patient and disease characteristics. CONCLUSION: Patients who received Mohs surgery had significantly longer OS when compared with those who received surgical excision. Prospective clinical trials comparing these treatment paradigms are warranted. Abstract : Supplemental Digital Content is Available in the Text.