2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks. (12th August 2019)

• Record Type: Journal Article
• Authors: Merg, Andrea D.; Touponse, Gavin; van Genderen, Eric; Zuo, Xiaobing; Bazrafshan, Alisina; Blum, Thorsten; Hughes, Spencer; Salaita, Khalid; Abrahams, Jan Pieter; Conticello, Vincent P.
• Is Part Of: Angewandte Chemie. Volume 131:Number 38(2019)
• Page Start: 13641
• Page End: 13646
• Publication Date: 2019-08-12
• Subjects: Biomaterialien -- Collagen -- Peptide -- Nanoschichten -- Selbstorganisation; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201906214
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: The successful integration of 2D nanomaterials into functional devices hinges on developing fabrication methods that afford hierarchical control across length scales of the entire assembly. We demonstrate structural control over a class of crystalline 2D nanosheets assembled from collagen triple helices. By lengthening the triple helix unit through sequential additions of Pro‐Hyp‐Gly triads, we achieved sub‐angstrom tuning over the 2D lattice. These subtle changes influence the overall nanosheet size, which can be adjusted across the mesoscale size regime. The internal structure was observed by cryo‐TEM with direct electron detection, which provides real‐space high‐resolution images, in which individual triple helices comprising the lattice can be clearly discerned. These results establish a general strategy for tuning the structural hierarchy of 2D nanomaterials that employ rigid, cylindrical structural units. Abstract : Nanoschicht‐Engineering : Die Feineinstellung von kristallinen 2D‐Nanoschichten über den sub‐nano‐ und mesoskaligen Maßstab wurde durch die systematische Justierung der Länge und Stabilität von Collagen‐Tipelhelices erreicht. Aus den Ergebnissen lassen sich Prinzipien für die Entwicklung und Konstruktion von maßgeschneiderten 2D‐Nanomaterialien ableiten, die aus starren, helicalen Strukturmotiven wie α‐Helices und gewendelte Spiralen aufgebaut sind.