Autoantibody profile in children with Kawasaki disease on long‐term follow‐up: A prospective study from North India. (30th August 2018)

• Record Type: Journal Article
• Authors: Basha, Aseem; Rawat, Amit; Jindal, Ankur K.; Gupta, Anju; Anand, Shashi; Garg, Ravinder; Minz, Ranjana W.; Singh, Surjit
• Is Part Of: International journal of rheumatic diseases. Volume 21:Number 11(2018)
• Page Start: 2036
• Page End: 2040
• Publication Date: 2018-08-30
• Subjects: anti‐neutrophil cytoplasmic antibody -- antinuclear antibody -- autoantibodies -- Kawasaki disease -- thyroid microsomal antibody; Rheumatology -- Periodicals; Rheumatology -- Asia -- Periodicals; Rheumatology -- Pacific Area -- Periodicals; Rheumatic Diseases -- Periodicals; Connective Tissue Diseases -- Periodicals; Immune System Diseases -- Periodicals; 616.723
• DOI: 10.1111/1756-185X.13372
• Languages: English
• ISSNs: 1756-1841

Abstract

Abstract: Aim: To study the profile of autoantibodies on long‐term follow‐up of children with Kawasaki disease (KD). Patients and methods: In this single‐center observational cohort study, 50 children who had been diagnosed and treated for KD with a minimum follow‐up period of 3 years were enrolled. The organ‐specific autoantibodies that were assessed in the study included anti‐thyroid microsomal antibody (TMA), anti‐parietal cell antibody (PCA) and anti‐liver kidney microsomal (LKM) antibody. The organ‐nonspecific autoantibodies that were studied included anti‐endothelial cell antibody (AECA), anti‐nuclear antibody (ANA), anti‐neutrophil cytoplasmic antibody (ANCA), anti‐mitochondrial antibody (AMA) and anti‐smooth muscle antibody (SMA). Results: The sample for assessment of serology was taken at a mean follow‐up period of 6.41 years (±1.95 SD) after diagnosis. Autoantibodies were detected in 11/50 (22%) patients. ANA was detected in three patients, TMA was positive in seven and ANCA was positive in one. Conclusions: These autoantibodies likely develop in children with KD during the acute stage and may persist for many years. There is no concrete evidence to suggest that these children are at increased risk of developing an autoimmune disease in the future. However, there is some justification for prolonged surveillance for development of autoimmune manifestations.