Radionuclide‐Activated Nanomaterials and Their Biomedical Applications. Issue 38 (8th July 2019)

• Record Type: Journal Article
• Authors: Ferreira, Carolina A.; Ni, Dalong; Rosenkrans, Zachary T.; Cai, Weibo
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 38(2019)
• Page Start: 13232
• Page End: 13252
• Publication Date: 2019-07-08
• Subjects: Cerenkov radiation -- nanomedicine -- radioactivation -- radionuclides -- theranostics; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201900594
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Radio‐nanomedicine, or the use of radiolabeled nanoparticles in nuclear medicine, has attracted much attention in the last few decades. Since the discovery of Cerenkov radiation and its employment in Cerenkov luminescence imaging, the combination of nanomaterials and Cerenkov radiation emitters has been revolutionizing the way nanomaterials are perceived in the field: from simple inert carriers of radioactivity to activatable nanomaterials for both diagnostic and therapeutic applications. Herein, we provide a comprehensive review on the types of nanomaterials that have been used to interact with Cerenkov radiation and the gamma and beta scintillation of radionuclides, as well as on their biological applications. Abstract : Nuclear option : Recent developments in radionuclide‐activated nanomaterials are systemically summarized in this Review. The focus lies in highlighting the interactions between radionuclides and nanomaterials (e.g., Cerenkov radiation, gamma and beta scintillation, etc.) as well as their biomedical applications.