Mimicry by a viral RHIM. (21st January 2019)

• Record Type: Journal Article
• Authors: Mompeán, Miguel; Bozkurt, Gunes; Wu, Hao
• Is Part Of: EMBO reports. Volume 20:Number 2(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-01-21
• Subjects: Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.15252/embr.201847433
• Languages: English
• ISSNs: 1469-221X

Abstract

Abstract : Functional amyloids have recently attracted much attention due to their involvement in signalling pathways, with hybrid amyloid formation showcasing a key role in necroptosis. In this issue of EMBO Reports, Sunde and colleagues 1 unveil that hybrid amyloids are central to necroptosis more broadly, uncovering the amyloidal nature of viral‐induced necrosome assemblies. They also prove that the mechanism by which murine cytomegalovirus unleashes necroptosis also relies on hybrid amyloid assembly by viral proteins, akin to that used by host cells. This study presents a way to selectively inhibit necroptosis in which amyloid assembly can be exploited further as a potential therapeutic target. Abstract : A report in this issue describes that the murine herpesvirus cytomegalovirus triggers necroptosis via hybrid amyloid assemblies by viral proteins similar to those used by host cells, suggesting means to selectively inhibit virus‐induced necroptosis.