Incidence of soft tissue sarcoma in Taiwan: A nationwide population-based study (2007–2013). (June 2019)

• Record Type: Journal Article
• Authors: Hung, Giun-Yi; Horng, Jiun-Lin; Chen, Paul Chih-Hsueh; Lin, Li-Yih; Chen, Jinn-Yang; Chuang, Pei-Hung; Chao, Ta-Chung; Yen, Chueh-Chuan
• Is Part Of: Cancer epidemiology. Volume 60(2019:Jun.)
• Page Start: 185
• Page End: 192
• Publication Date: 2019-06
• Subjects: STS Soft tissue sarcoma -- GIST gastrointestinal stromal tumor -- WHO World Health Organization -- TCR Taiwan Cancer Registry -- DFSP Dermatofibrosarcoma protuberans -- ICD-O-3 International Classification of Diseases for Oncology Third Edition -- IARC International Agency for Research on Cancer -- MV% percentage of microscopy-verified registration -- DCO% percentage of death certificate only -- HWDC Health and Welfare Data Science Center -- UPS undifferentiated pleomorphic sarcoma -- MFH malignant fibrous histiocytoma -- NOS not otherwise specified -- CI confidence interval -- SIRR standardized incidence rate ratio -- ASIR age-standardized incidence rate -- APC annual percentage change -- HIV human immunodeficiency virus; Soft tissue -- Sarcoma -- Incidence -- Population-based -- Taiwan; Cancer -- Epidemiology -- Periodicals; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Carcinogenesis -- Periodicals; 616.994005
• DOI: 10.1016/j.canep.2019.04.007
• Languages: English
• ISSNs: 1877-7821

Abstract

Highlights: Totally, 11, 393 soft tissue sarcoma cases were included. Gastrointestinal stromal tumor was the most common subtype (29.2%). Angiosarcoma incidence was higher in Taiwan than in the United States and Europe. Leiomyosarcoma and Kaposi sarcoma incidence was low in Taiwan. Abstract: Background: Asian studies on soft tissue sarcoma (STS) incidence, irrespective of the primary site, are scant. Methods: STS data were acquired from the population-based 2007–2013 Taiwan Cancer Registry of the Health and Welfare Data Science Center, Taiwan. Histological subtype-, site-, sex-, and age-specific STS incidence rates were analyzed according to the 2013 classification of the World Health Organization. Results: In total, 11, 393 patients with an age-standardized incidence rate (ASIR) of 5.62 (95% confidence interval, 5.51–5.73) per 100, 000 person-years were identified. Overall, a male predominance (sex-standardized incidence rate ratio, 1.2) was noted, and the rate increased with age, peaking at >75 years. Approximately 30% of STSs occurred in connective, subcutaneous, and other soft tissues and 70% in other sites. In addition to connective, subcutaneous, and other soft tissues, the three most common primary sites were the stomach (15.9%), skin (14.3%), and small intestines (10.5%). Gastrointestinal stromal tumor was the most common subtype (29.2%; ASIR, 1.55/100, 000 person-years), followed by liposarcoma (11.5%; ASIR, 0.63/100, 000 person-years) and leiomyosarcoma (9.7%; ASIR, 0.53/100, 000 person-years). Compared with relevant data from Western countries, the incidence rate of angiosarcomas was higher than that in other regions, whereas the incidence rates of leiomyosarcoma and Kaposi sarcoma were lower than those in other regions. Conclusion: STS incidence varied by histological subtype, sex, age, and primary site in an Asian population. Our results suggested regional and racial discrepancies in the incidence rates of certain STS subtypes.