Pathological Gambling in Parkinson's disease: Autonomic measures supporting impaired decision‐making. (4th August 2018)

• Record Type: Journal Article
• Authors: Angioletti, Laura; Siri, Chiara; Meucci, Nicoletta; Pezzoli, Gianni; Balconi, Michela
• Is Part Of: European journal of neuroscience. Volume 50:Number 3(2019)
• Page Start: 2392
• Page End: 2400
• Publication Date: 2018-08-04
• Subjects: autonomic measures -- behavioral addiction -- Iowa Gambling Task -- Parkinson's disease -- pathological gambling -- somatic marker hypothesis; Nervous system -- Periodicals; 612.8
• DOI: 10.1111/ejn.13993
• Languages: English
• ISSNs: 0953-816X

Abstract

Abstract: According to the somatic marker hypothesis, autonomic measures and arousal modulation can reveal a difference in subgroups of patients developing impaired decision‐making because of addictions. Previously, pathological gambling (PG) and Parkinson's disease (PD) have been associated with differential arousal levels during gambling behavior. However, no research considered the specific autonomic responses of Parkinson's disease patients with pathological gambling and with a previous history of gambling. Thus, this study investigated skin conductance responses (SCRs), skin conductance level (SCL) and heart rate (HR) during the Iowa Gambling Task (IGT) in two groups of PD patients with gambling disorder, active (PD Gamblers; n = 14) or remitted (PD Non‐Gamblers; n = 13) and a control group of patients with Parkinson's disease only ( n = 13). Anticipatory autonomic responses to disadvantageous decks and advantageous decks during the Iowa Gambling Task were measured for each participant. The PD Gamblers group performed worse than the PD Non‐Gamblers and the control groups at the IGT task and exhibited lower SCRs, SCL, and HR during the decision‐making processing of cards belonging to disadvantageous decks. The role of autonomic and behavioral measures was considered. Abstract : Previously, Pathological Gambling and Parkinson's Disease (PD) have been associated with differential arousal levels during gambling behavior. However, no research compared the specific autonomic responses of PD Gamblers to those of PD patients with a previous history of gambling. Here, PD Gamblers exhibited lower Skin Conductance Responses, Skin Conductance Level and Heart Rate than the PD Non‐Gamblers and the PD control groups, during the decision‐making processing of Iowa Gambling Task disadvantageous decks.