Effect of Disease Severity on Respiratory Impedance in Parkinson's Disease. Issue 2 (April 2020)

• Record Type: Journal Article
• Authors: Sampath, Meghashree; Srivastava, Achal Kumar; Goyal, Vinay; Jaryal, Ashok Kumar; Deepak, Kishore Kumar; Talwar, Anjana
• Is Part Of: Annals of neurosciences. Volume 27:Issue 2(2020)
• Page Start: 63
• Page End: 66
• Publication Date: 2020-04
• Subjects: Airway resistance -- Impulse Oscillometry -- motor disorder -- Parkinson's disease -- pulmonary function -- spirometry; Neurosciences -- Periodicals; Nervous system -- Diseases -- Periodicals; Nervous system -- Diseases; Neurosciences; Nervous System Diseases; Periodicals; Electronic journals; Electronic journals; Periodical; 616.8
• DOI: 10.1177/0972753120960265
• Languages: English
• ISSNs: 0972-7531

Abstract

Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder. PD has been traditionally perceived as a motor disorder. However, it is frequently associated with pulmonary dysfunction which has been assessed by Spirometry, an effort-dependent technique. Purpose: To evaluate in patients with PD the effect of disease severity on respiratory impedance using Impulse Oscillometry (IOS) and to correlate with Spirometry. Methods: The study was conducted on 30 patients diagnosed with PD. Pulmonary function was assessed by IOS and spirometer. IOS is an effort-independent technique that uses sound waves of different frequencies to measure airway resistance. Spirometer measures the lung volume and generates flow–volume and volume–time relationship. Results: The mean age of patients was 60.1±9.45. Resistance at 5 Hz (R5) was found to be negatively correlated with forced expiratory volume in the first second of the FVC manoeuver (FEV1 ) ( r = –0.628, P = .002), FEV1 /FVC (forced vital capacity) ( r = –0.487, P = .025), and PEF ( r = –0.599, P = .004), and resistance at 20 Hz (R20) with FEV1 ( r = –0.474, P = .029) and PEF ( r = –0.522, P = .015). There was significant increase in R5 (0.32(0.36–0.28) vs 0.47(0.60–0.36); P = .04) and R20 (0.25(0.28–0.20) vs 0.30(0.40–0.25); P = .04) in stage II as compared to stage I of Hoehn–Yahr scale. Conclusion: IOS might be a promising tool for diagnosis of respiratory dysfunction in addition to Spirometry, especially in cases where patients are not able to perform forced manoeuvers.