Alzheimer's genetic risk intensifies neurocognitive slowing associated with diabetes in nondemented older adults. Issue 4 (2nd September 2015)

• Record Type: Journal Article
• Authors: McFall, G. Peggy; Wiebe, Sandra A.; Vergote, David; Anstey, Kaarin J.; Dixon, Roger A.
• Is Part Of: Alzheimer's & dementia. Volume 1:Issue 4(2015)
• Page Start: 395
• Page End: 402
• Publication Date: 2015-09-02
• Subjects: Alzheimer's disease genetic risk score -- APOE -- Type 2 diabetes -- Neurocognitive speed -- Victoria longitudinal study; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1016/j.dadm.2015.08.002
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: We examine interactive and intensification effects of type 2 diabetes (T2D) with APOE and an Alzheimer's disease genetic risk score (GRS) on neurocognitive speed performance and change in nondemented older adults. Methods: In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baseline median age = 69.0) followed over 9 years. The GRS was compiled using the cumulative risk of APOE, CLU, CR1, and PICALM . Results: First, T2D predicted slower speed performance at centering age (75). Second, no predictive effects were associated with APOE or GRS. Third, a significant interaction showed that high risk from both T2D and GRS was selectively associated with steeper longitudinal slowing than all comparison cross‐domain risk groups. Discussion: Higher AD‐related genetic risk intensified deleterious effects of diabetes on neurocognitive slowing in nondemented aging beyond the independent influence of APOE .