P303 Role of parietal healing by ultrasound in the evolution of patients with Crohn's disease. (15th January 2020)

• Record Type: Journal Article
• Authors: Mayor Delgado, P; Suarez Ferrer, C J; Poza Cordon, J; Martin Arranz, E; Rueda Garcia, J L; Sanchez Azofra, M; Cuadros Martinez, M; Ruiz Ramirez, M A; Martin Arranz, M D
• Is Part Of: Journal of Crohn's and colitis. Volume 14(2020)Supplement 1
• Page Start: S304
• Page End: S305
• Publication Date: 2020-01-15
• Subjects: Inflammatory bowel diseases -- Periodicals; 616.344005
• DOI: 10.1093/ecco-jcc/jjz203.432
• Languages: English
• ISSNs: 1873-9946

Abstract

Abstract: Background: The objective of this study is to assess the degree of parietal involvement with ultrasound and see how they influence the prognosis according to the findings. Methods: It was defined as 'parietal healing' the normalisation of ultrasound findings in a previously affected segment (parietal thickness less than 3 mm and absence of parietal hyperaemia). Therefore, patients with absence of ultrasound activity but without reaching parietal healing were considered to be those without significant inflammatory signs (parietal thickness <4.5 mm and absence of hyperaemia or other inflammatory data) but who had not 'normalised' the previously affected segment. Results: A total of 111 patients without ultrasound inflammatory activity were included. It was studied whether normalisation of parameters in a previously affected segment, i.e. parietal healing gave a better prognosis during follow-up. It was detected that 74 patients achieved 'parietal healing' and this subgroup of patients generally had a flare in 12% of cases (9/74 patients) compared with 27% of cases (10/37) among patients without parietal healing, these differences were statistically significant ( p = 0.05). Similar, it was identified that among patients without ultrasound activity who had a subsequent outbreak during follow-up, the median survival was lower (1, 09 years) in patients without parietal healing vs. those with parietal healing (1.4 years), the differences reaching statistical significance ( p = 0.03). Likewise, during the follow-up, it was objectived, by means of survival analysis, that the evolution of patients without ultrasound activity was more favourable in those with 'parietal healing' with remission 95% vs. 90% at first year, 89% vs. 81% at 2 years and 85% vs. 66% at 3 years of follow-up. The results are outlined in Figure 1. Conclusion: To conclude, detecting parietal healing by ultrasound improves prognosis by decreasing the number of outbreaks and increasing the median survival until outbreaks occur.