Role of UHRF1 in malignancy and its function as a therapeutic target for molecular docking towards the SRA domain. (September 2019)

• Record Type: Journal Article
• Authors: Polepalli, Sravani; George, Sophia M; Valli Sri Vidya, R; Rodrigues, Gabriel Sunil; Ramachandra, L.; Chandrashekar, Raghu; M, Deepak Nayak; Rao, Praveen P.N.; Pestell, Richard G.; Rao, Mahadev
• Is Part Of: International journal of biochemistry & cell biology. Volume 114(2019)
• Publication Date: 2019-09
• Subjects: TSGs Tumour suppressor genes -- ICBP90 Inverted CCAAT box binding protein 90 -- UHRF1Ubiquitin-like with containing PHD and RING Finger domains 1 -- UBL Ubiquitin-like domain -- TTD Tandem Tudor domain -- PHD Plant Homeo Domain -- SRA Set and Ring Associated -- RING Really Interesting New Gene -- NIRF_N Novel Np95/ ICBP90-like RING finger protein N-terminus -- DNMT1 DNA methyltransferase 1 -- HDAC1 Histone deacetylase 1 -- EMT Endothelial to mesenchymal transition -- LSCC Laryngeal squamous cell carcinoma -- ESCC Esophageal squamous cell carcinoma -- OS Overall survival -- PFS Progression-free survival -- EGCG Epigallocatechin-3-gallate -- TQ Thymoquinone -- NASTRP Naphthol AS-TR phosphate -- DHA Dihydroartemisinin -- MDR Multidrug resistance; UHRF1 -- Universal oncogene -- Cancer -- SRA domain; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2019.06.006
• Languages: English
• ISSNs: 1357-2725

Abstract

Graphical abstract: Highlights: UHRF1 is upregulated in several cancers. UHRF1 levels are associated with stage, size and grade of the tumor. UHRF1 can be used as a druggable target. Docking of Propranolol, Nocodazole, Thymoquinone, Emodin, Napthazarin to SRA domain. Abstract: The figure describes the location of UHRF1 (Ubiquitin-like with containing PHD and RING Finger domains 1) gene, mRNA and protein synthesis in the tumor cell and its structural domains with a focus on the docking of Naphthazarin on the SRA domain of UHRF1, resulting in reduction of tumor size.