Self‐Assembly of Wireframe DNA Nanostructures from Junction Motifs. Issue 35 (24th July 2019)

• Record Type: Journal Article
• Authors: Huang, Kai; Yang, Donglei; Tan, Zhenyu; Chen, Silian; Xiang, Ye; Mi, Yongli; Mao, Chengde; Wei, Bryan
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 35(2019)
• Page Start: 12123
• Page End: 12127
• Publication Date: 2019-07-24
• Subjects: DNA nanostructures -- junction motifs -- self-assembly -- wireframe structures; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201906408
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Wireframe frameworks have been investigated for the construction of complex nanostructures from a scaffolded DNA origami approach; however, a similar framework is yet to be fully explored in a scaffold‐free "LEGO" approach. Herein, we describe a general design scheme to construct wireframe DNA nanostructures entirely from short synthetic strands. A typical edge of the resulting structures in this study is composed of two parallel duplexes with crossovers on both ends, and three, four, or five edges radiate out from a certain vertex. By using such a self‐assembly scheme, we produced planar lattices and polyhedral objects. Abstract : Conjunction junction, what's your function? Junction motifs of specific angle arrangements are designed. 2D wireframe lattices and 3D wireframe polyhedra are constructed accordingly.