Importance of lymphovascular invasion and invasive front on survival in floor of mouth cancer. (25th November 2015)

• Record Type: Journal Article
• Authors: Fives, Cassie; Feeley, Linda; O'Leary, Gerard; Sheahan, Patrick
• Is Part Of: Head & neck. Volume 38(2016)Supplement 1
• Page Start: E1528
• Page End: E1534
• Publication Date: 2015-11-25
• Subjects: floor of mouth -- oral cavity -- squamous cell carcinoma -- lymphovascular invasion -- invasive front; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24273
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The floor of mouth (FOM) is a common site of oral squamous cell carcinoma (SCC). The purpose of this study was to investigate pathological predictors of survival in FOM SCC. Methods: We conducted a retrospective study of 54 consecutive patients undergoing surgery for FOM SCC. Pathological parameters were extracted from histological reports with original pathology slides re‐reviewed by 2 pathologists for missing data. Results: On univariate analysis, depth of invasion >10 mm ( p = .009), lymphovascular invasion (LVI; p < .001), noncohesive invasive front ( p = .006), perineural invasion (PNI; p = .003), and nodal metastases ( p = .02) were significant predictors of overall survival. On multivariate analysis, LVI ( p = .009) and invasive front ( p < .001) remained significant. Postoperative radiotherapy improved survival in patients with LVI, PNI, and nodal metastases, and was just outside significance for noncohesive invasive front ( p = .06). Conclusion: LVI is an adverse prognosticator in FOM SCC and indicates postoperative radiotherapy. Further study is required to investigate the importance of invasive front. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E1528–E1534, 2016