Induction docetaxel and S‐1 followed by concomitant radiotherapy with low‐dose daily cisplatin in locally advanced head and neck carcinoma. (18th February 2016)

• Record Type: Journal Article
• Authors: Kim, Hye Ryun; Lee, Chang Geol; Choi, Eun Chang; Kim, Joo Hang; Koh, Yoon Woo; Cho, Byoung Chul
• Is Part Of: Head & neck. Volume 38(2016)Supplement 1
• Page Start: E1653
• Page End: E1659
• Publication Date: 2016-02-18
• Subjects: head and neck -- squamous cell carcinoma -- docetaxel -- S‐1 -- induction chemotherapy; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24294
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The purpose of this study was to assess the efficacy and safety of induction chemotherapy with docetaxel‐S‐1, and radiotherapy (RT) with concurrent daily cisplatin in locally advanced head and neck carcinoma. Method: Fifty patients received 2 cycles of induction chemotherapy with induction chemotherapy with docetaxel and S‐1, followed by 7 cycles of RT with concurrent daily cisplatin. Results: The most frequent grade 3 to 4 hematologic toxicity was neutropenia (14%). Forty of 50 patients who completed induction chemotherapy with docetaxel and S‐1 subsequently started RT with concurrent daily cisplatin, all within 3 to 4 weeks after the start of the second cycle of induction chemotherapy with docetaxel and S‐1. The best response to induction chemotherapy with docetaxel and S‐1 and after completion of RT with concurrent daily cisplatin was partial response (PR) in 52.5% and complete response in 47.5%, respectively. With a median follow‐up of 61 months, 5‐year progression‐free survival (PFS) and overall survival (OS) were 63.3% and 65.7%, respectively. Conclusion: Administration of induction chemotherapy with docetaxel and S‐1 before RT with concurrent daily cisplatin chemoradiotherapy (CRT) resulted in a high response rate with good tolerability, and did not compromise subsequent CRT. © 2016 Wiley Periodicals, Inc. Head Neck 38 : E1653–E1659, 2016